Tablet containing steroid hormones

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61K 31/56 (2006.01) A61K 31/568 (2006.01) A61P 5/24 (2006.01) A61P 5/26 (2006.01) A61P 5/30 (2006.01) A61P 5/44 (2006.01)

Patent

CA 2598892

The invention concerns a pharmaceutical composition in the form of a film- shaped system for transmucosal delivery of steroid hormones. The invention concerns in particular a system for delivering steroid hormones which dissolves in the oral cavity and releases the active substances with high bioavailability. Said film-shaped delivery system dissolves in the oral cavity preferably in less than 30 minutes, the steroid hormone which passes through the trasmucosal route of the delivery system to a blood circuit rapidly increasing concentration in the blood. The steroid hormone concentration in the blood can reach a maximum level in less than 60 minutes after delivery.

L'invention concerne une composition pharmaceutique se présentant sous la forme d'un système sous forme de film destiné à l'administration d'hormones stéroïdes par voie transmuqueuse. L'invention concerne notamment un système d'administration d'hormones stéroïdes qui se dissout dans la cavité buccale et qui libère les substances actives avec une biodisponibilité élevée. Ce système d'administration sous forme de film se dissout dans la cavité buccale de préférence en moins de 30 minutes, l'hormone stéroïde qui passe par voie transmuqueuse du système d'administration au circuit sanguin entraînant une augmentation rapide de la concentration dans le sang. La concentration de l'hormone stéroïde dans le sang peut ainsi atteindre un niveau maximum en moins de 60 minutes après administration.

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