Tablets made from sustained release microcapsules

Details Tablets made from sustained release microcapsules Tablets made from sustained release microcapsules

A - Human Necessities

61

K

167/164

A61K 9/20 (2006.01) A61K 9/46 (2006.01) A61K 9/52 (2006.01)

Patent

CA 1312283

ABSTRACT A tablet for oral administration of a sustained- release active ingredient is formed by compressing microcapsules containing the active ingredient. The microcapsules are of a size range of between about 5 and about 400 microns, and comprise particles of active ingredient coated with a thin layer of sustained release coating which is sufficiently flexible that the coated particles may be compressed into a tablet without breaking the integrity of the coating. The sustained release coating may be ethyl cellulose if it has a molecular weight such that it evidences a viscosity of at least 25 cps. Alternatively, any conventional sustained release coating, including low viscosity ethyl cellulose, may be used if an extraordinarily high percentage of plasticizer, preferably within the range of about 15 to about 30% of the weight of the sustained release polymer in the coating, is added. Excipients causing disintegration of the tablet after administration and, optionally, effervescence, can be uniformly mixed with the microcapsules prior to compression.

543094

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