Tablets with improved drug substance dispersibility

A - Human Necessities – 61 – K

Patent

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A61K 9/20 (2006.01)

Patent

CA 2598762

The present invention relates to a method for the preparation of pharmaceutical compositions in the form of tablets with improved drug substance dispersibility, said method being characterized in that it comprises the steps of: a) preparing a dispersion of at least one pharmaceutically active drug substance and at least one surfactant and/or binder in a liquid; b) preparing a carrier by dry blending one or more excipient(s) including at least one porous carrier; and c) spray granulating the dispersion prepared under a) onto the carrier prepared under b) in order to obtain a spray- granulated product.

La présente invention se rapporte à un procédé permettant de préparer des compositions pharmaceutiques se présentant sous forme de comprimés et dotées d'une dispersibilité de substance médicamenteuse améliorée. Ledit procédé est caractérisé en ce qu'il comprend les étapes suivantes : (a) préparation d'une dispersion d'au moins une substance médicamenteuse pharmaceutiquement active et d'au moins un tensio-actif et/ou un liant dans un liquide ; (b) préparation d'un véhicule, par le mélange sec d'un ou plusieurs excipients, dont au moins un véhicule poreux ; et (c) granulation par pulvérisation de la dispersion préparée à l'étape (a) sur le véhicule préparé à l'étape (b), afin d'obtenir un produit de granulation par pulvérisation.

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