Tachiquinine antagonist tricyclic compounds, preparation of...

C - Chemistry – Metallurgy – 07 – K

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C07K 7/64 (2006.01) A61K 38/12 (2006.01) C07K 7/22 (2006.01) C07K 7/50 (2006.01) C07K 7/56 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2118253

2118253 9321227 PCTABS00027 A description is given of tachykinin antagonist tricyclic compounds having general formula (I) where: X1, X2, X3, X4, X5, and X6, identical or different, are each selected out of the group consisting of -NR'-CO-, -CO-NR'-, where R' is H or C1-3alkyl; Y is selected out of the group consisting of -CONR-, NRCO-, -OCO-, -COO-, -CH2-NR-, -NR-CH2-, -SS-, -CH2-CH2-, cis or trans -CH=CH-, where R is H or C1-3alkyl; R1, R2, R3, and R4 are each a hydrophobic group; n and m, identical or different, are each a whole number from 1 to 4, the preparation of same and pharmaceutical compositions containing said compounds.

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