Tachykinin antagonists

Details Tachykinin antagonists Tachykinin antagonists

C - Chemistry, Metallurgy

07

D

C07D 209/20 (2006.01) A61K 31/27 (2006.01) A61K 31/33 (2006.01) C07C 271/20 (2006.01) C07C 271/22 (2006.01) C07D 209/30 (2006.01) C07D 231/56 (2006.01) C07D 307/81 (2006.01) C07D 333/24 (2006.01) C07D 333/60 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2140640

Compounds of formula (I) wherein R, R8 and R6 are possibly substituted phenyl, pyridine, thiophene, furan, naphtha- lene, etc.; R1 and R2 are each independently hydrogen or alkyl of from 1 to 4 atoms; R and R2, when joined by a bond, can form a ring; X is a wherein R11 is hydrogen or alkyl of from 1 to 3 carbon atoms; R3 is hydrogen or (CH2)mR13 where m is an integer of from 1 to 6 and R13 is H, CN, NH2, N(CH3)2, or NHCOCH3; n is an integer of from 1 to 2; Y is .beta. wherein R4 is hydrogen or alkyl of from 1 to 3 carbon atoms, -CO2-, etc.; R5 and R7 are each independently hydrogen or alkyl of from 1 to 4 carbon atoms; q is an integer of from 0 to 1. The compounds are nonpeptide tachykinin antagonists and are expected to be especially useful in asthma and rheumatoid arthritis.

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