Tacis and br3 polypeptides and uses thereof

Details Tacis and br3 polypeptides and uses thereof Tacis and br3 polypeptides and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/28 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2453995

Novel receptors, referred to herein as "TACIs" and "BR3", agonists and antagonists thereof, and methods of using TACIs and BR3, as well as agonists or antagonists thereof, to modulate for example, activity of tumor necrosis factor (TNF) and TNFR-related molecules, including members of the TNF and TNFR families referred to as TALL-1, APRIL, TACI, and BCMA, are provided. Methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with such TNF and TNFR-related molecules are further provided.

L'invention concerne de nouveaux récepteurs, ci-après dénommés <=TACI >= et <= BR3 >=, des agonistes et des antagonistes de ces derniers, ainsi que des procédés d'utilisation des TACI et des BR3, et de leurs agonistes et antagonistes, afin de moduler, par exemple, l'activité du facteur de nécrose tumorale (TNF) et des molécules liées au récepteur du TNF (TNFR), notamment des membres des familles du TNF et du TNFR dénommés TALL-1, APRIL, TACI et BCMA. L'invention concerne également des procédés de diagnostic et/ou de traitement in vitro, in situ, et/ou in vivo de cellules de mammifères ou d'états pathologiques associés auxdites molécules liées au TNF et au TNFR.

Affiliated with

Also associated with

Rating

Tacis and br3 polypeptides and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tacis and br3 polypeptides and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tacis and br3 polypeptides and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1447504