A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/122 (2006.01) A61K 31/05 (2006.01) A61K 31/055 (2006.01) A61P 3/00 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2622523
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed.
L'invention porte sur des procédés qui permettent de traiter et d'éliminer les maladies mitochondriales telles que l'ataxie de Friedreich ("Friedreich's ataxia" ou FRDA), la neuropathie optique héréditaire de Leber ("Leber's Hereditary Optic Neuropathy" ou LHON), la myopathie mitochondriale, l'encéphalopathie, l'acidose lactique, le syndrome MELAS ou le syndrome de Kearns-Sayre (KSS), et sur des composés utilisés selon les procédés de l'invention. L'invention concerne également des biomarqueurs énergétiques qui sont utilisés pour évaluer l'état métabolique d'un sujet et l'efficacité du traitement.
Hecht Sidney M.
Miller Guy M.
Borden Ladner Gervais Llp
Edison Pharmaceuticals Inc.
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