C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/00 (2006.01) C12N 15/10 (2006.01) C12N 15/62 (2006.01) C12P 7/00 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2384972
The invention relates to novel made-to-measure, artificial non-ribosomal peptide-synthetases (NRPS) for the non-ribosomal synthesis and/or modification of peptides of a predetermined length and composition and/or the modification of individual amino acids. By fusing units of the peptide synthetases in specific linker areas, using a "modular molecular tool kit" it is possible to produce NRPS in a targeted manner, which are capable of synthesising peptides of a desired structure.
La présente invention concerne des synthétases de peptides, non ribosomales, artificielles et individualisées (NRPS), destinées à la synthèse et/ou à la modification non ribosomale de peptides de longueur et de composition données et/ou à la modification d'acides aminés individuels. Par fusion des unités de synthétases de peptides dans des zones de lieurs données, il est possible, à l'aide d'une <= trousse de construction moléculaire modulaire >=, de produire des NRPS de façon ciblée, ces dernières étant capables de synthétiser des peptides de structure souhaitée.
Dokel Sascha
Linne Uwe
Marahiel Mohamed A.
Mootz Henning
Schwarzer Dirk
Dokel Sascha
Fetherstonhaugh & Co.
Linne Uwe
Marahiel Mohamed A.
Mootz Henning
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