Talarazole metabolites

Details Talarazole metabolites Talarazole metabolites

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/428 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2667053

Novel metabolites of talarazole of formula (I) have been isolated and characterized, wherein R = H, OH, OSO3H or O-gly; R1, = H, OH, OSO3H, O-gly or =0; and gly = a glucuronate, or a pharmaceutically acceptable salt thereof. These compounds are targeted for the treatment of various skin-, hair- and nail-associated disorders.

L'invention concerne de nouveaux métabolites de talarazole de formule (I), lesdits métabolites ayant été isolés et caractérisés, avec R = H, OH, OSO3H ou O-gly; R1, = H, OH, OSO3H, O-gly ou =0; et gly = un glucuronate ou un de ses sels pharmaceutiquement acceptables. Ces composés sont ciblés pour le traitement de divers troubles associés à la peau, les cheveux et les ongles.

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