A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 38/12 (2006.01) A61K 38/14 (2006.01) C07K 5/02 (2006.01) C07K 5/083 (2006.01) C07K 7/02 (2006.01) C07K 9/00 (2006.01) C07K 11/00 (2006.01) C07K 17/00 (2006.01)
Patent
CA 2405779
The present invention relates to didemnin analogs, including tamandarin analogs and didemnin and tamandarin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of using them as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.
La présente invention concerne des analogues de didemnine, y compris des analogues de tamandarine et des analogues de didemnine et de tamandarine qui présentent un résidu de déoxo-proline ou un résidu de déhydro-proline dans leur structure. On utilise ces analogues comme agents anticancéreux et à d'autres fins. Cette invention concerne également les méthodes de fabrication de ces analogues et de leur utilisation en tant qu'inhibiteurs de la synthèse protéique, de la croissance cellulaire et de la tumorigenèse et en tant qu'amplificateurs de l'apoptose.
Ding Xiaobin
Joullie Madeleine M.
Liang Bo
Gowling Lafleur Henderson Llp
The Trustees Of The University Of Pennsylvania
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