Tamper resistant co-extruded dosage form containing an...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61J 3/06 (2006.01) A61J 3/07 (2006.01) A61K 9/24 (2006.01) A61K 9/56 (2006.01) A61K 45/06 (2006.01) A61K 47/32 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2548834

The present invention relates to co-extruded pharmaceutical compositions and dosage forms including an active agent, such as an opioid agonist, and an adverse agent, such as an opioid antagonist. Such compositions and dosage forms are useful for preventing or discouraging tampering, abuse, misuse or diversion of a dosage form containing an active pharmaceutical agent, such as an opioid. The present invention also relates to methods of treating a patient with such a dosage form, as well as kits containing such a dosage form with instructions for using the dosage form to treat a patient.

La présente invention concerne des compositions pharmaceutiques et des formes posologiques co-extrudées contenant un principe actif, tel qu'un agoniste opioïde, et un principe contraire, tel qu'un antagoniste opioïde. De telles compositions et formes posologiques sont conçues pour empêcher ou décourager une altération, un abus, une mauvaise utilisation ou un détournement d'une forme posologique contenant un principe pharmaceutique actif tel qu'un opioïde. Cette invention concerne également des méthodes de traitement de patients au moyen d'une telle forme posologique ainsi que des trousses contenant ladite forme posologique assorties d'instructions d'utilisation.

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