Tamper resistant dosage form comprising an adsorbent and an...

A - Human Necessities – 61 – K

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A61K 9/14 (2006.01)

Patent

CA 2557839

Pharmaceutical compositions and dosage forms comprising an adsorbent, and an adverse agent, such as an opioid antagonist. In one embodiment, at least a portion of the adverse agent is on the surface or within the micropore structure of an adsorbent material. The pharmaceutical compositions and dosage forms comprising the adsorbent and the adverse agent are useful for preventing or discouraging tampering, abuse, misuse or diversion of a dosage form containing an active pharmaceutical agent, such as an opioid. The present invention also relates to methods for treating a patient with such a dosage form, as well as kits containing such a dosage form with instructions for using the dosage form to treat a patient. The present invention further relates to process for preparing such pharmaceutical compositions and dosage forms.

Cette invention se rapporte à des compositions pharmaceutiques et à des formes posologiques, comprenant un adsorbant, et un agent adverse, tel qu'un antagoniste d'opioïdes. Dans un mode de réalisation, au moins une partie de l'agent adverse est placé sur la surface ou dans la structure microporeuse du matériau de l'adsorbant. Ces compositions pharmaceutiques et ces formes posologiques comprenant l'adsorbant et l'agent adverse sont utiles pour prévenir ou décourager toute violation, tout abus, toute mauvaise utilisation ou tout détournement d'utilisation d'une forme posologique contenant un agent pharmaceutique actif, tel qu'un opioïde. Cette invention concerne également des procédés pour traiter un patient au moyen d'une telle forme posologique, ainsi que des kits contenant une telle forme posologique avec les instructions d'utilisation de la forme posologique pour traiter un patient. Cette invention concerne en outre un procédé pour préparer ces compositions pharmaceutiques et ces formes posologiqes.

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