B - Operations – Transporting – 01 – D
Patent
B - Operations, Transporting
01
D
B01D 61/14 (2006.01) A61M 1/34 (2006.01) A61M 1/36 (2006.01) B01D 61/16 (2006.01) B01D 61/18 (2006.01) B01D 61/22 (2006.01) A61M 1/38 (2006.01)
Patent
CA 2490245
The present invention provides tangential flow filtration devices and methods for enriching a heterogeneous mixture of blood constituents for leukocytes by removal of non-leukocyte blood constituents. In one particular embodiment the device can provide a composition enriched in monocytes. One embodiment includes a remover unit (1) having a crossflow chamber (3) separated by a microporous filter (5) from a filtrate chamber (4), the remover unit (1) also having a tangential flow inlet (6), a fluid outlet (7) for a fluid enriched in leukocytes and a filtrate outlet (8).
La présente invention concerne des dispositifs de filtration tangentielle, ainsi que des méthodes permettant d'enrichir un mélange hétérogène de fractions sanguines pour les leucocytes, par retrait des fractions sanguines non leucocytaires. Dans un mode de réalisation particulier, le dispositif peut produire une composition enrichie en monocytes. Un mode de réalisation met en oeuvre une unité d'extraction (1) comprenant une chambre à débit transversal (3) séparée par un filtre microporeux (5) d'une chambre à filtrat (4). L'unité d'extraction (1) comprend également un orifice d'admission à écoulement tangentiel (6), un orifice de sortie (7) d'un liquide enrichi en leucocytes, et un orifice de sortie (8) d'un filtrat.
Bosch Marnix L.
Boynton Alton L.
Harris Paul C.
Lodge Patricia A.
Monahan Steven J.
Gowling Lafleur Henderson Llp
Northwest Biotherapeutics Inc.
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