C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 38/45 (2006.01) A61P 35/00 (2006.01) C07K 16/40 (2006.01) C12N 9/10 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2370568
The invention provides novel tankyrase polypeptides designated tankyrase2, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, and host cells transformed with the expression constructs. Also provided are methods for producing the tankyrase2 polypeptides, antibodies that are immunoreactive with the tankyrase2 polypeptides. In addition, there are provided methods for identifying specific binding partners of tankyrase2, and more particularly methods for identifying binding partners that modulate biological activity of tankyrase2. Methods of modulating biological activity of tankyrase2 <i>in vitro</i> and <i>in vivo</i> are also provided.
L'invention concerne de nouveaux polypeptides tankyrase nommés tankyrase2, des polynucléotides codant pour ces polypeptides, des constructions d'expression comprenant ces polynucléotides et des cellules hôtes transformées à l'aide des constructions d'expression. L'invention concerne également des méthodes permettant de produire ces polypeptides tankyrase2, des anticorps qui sont immunoréactifs avec ces polypeptides tankyrase2. L'invention concerne en outre des méthodes permettant d'identifier des partenaires de liaison spécifiques de tankyrase2, et notamment des méthodes permettant d'identifier des partenaires de liaison qui modulent l'activité biologique de tankyrase2. L'invention concerne enfin des méthodes permettant de moduler l'activité biologique de tankyrase2 <i>in vitro</i> et <i>in vivo</i>.
Christenson Erik
Demaggio Anthony J.
Goldman Phyllis S.
Mcelligott David L.
Icos Corporation
Smart & Biggar
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