C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/64 (2006.01) A61K 31/16 (2006.01) A61K 31/17 (2006.01) C07C 275/06 (2006.01) C07C 275/28 (2006.01)
Patent
CA 2542064
The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
L'invention concerne des composés et des méthodes destinés à l'inhibition de kinases, telles que celles de la famille TAO et plus précisément les kinases KIAA1361, TAO et JIK. L'invention concerne également des composés destinés à la modulation de l'activité enzymatique des protéines kinases et à la modulation des activités cellulaires, telles que la prolifération, la différenciation, l'apoptose, la migration et la chimio-invasion. Les composés de l'invention permettent d'inhiber, de réguler et/ou de moduler les voies de transduction de signal des récepteurs kinasiques associées aux changements d'activité cellulaire indiqués ci-dessus. L'invention concerne également des compositions contenant ces composés, ainsi que leurs méthodes d'utilisation pour le traitement de maladies et de troubles induits par les kinases.
Baly Deborah Lynn
Galan Adam Antoni
Ibrahim Mohamed Abdulkader
Jaeger Christopher
Kearney Patrick
Bennett Jones Llp
Exelixis Inc.
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