Tao protein kinases and methods of use therefor

Details Tao protein kinases and methods of use therefor Tao protein kinases and methods of use therefor

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 31/70 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2325824

Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase MEK3, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.

L'invention porte sur des compositions et procédés potentialisant l'activité de la protéine kinase p38 activée par le mitogène, et en particulier sur la protéine kinase MEK3 activée par le mitogène, et ses variantes stimulant la phosphorylation de la p38. Ces composés s'utilisent par exemple pour le traitement de maladies associées à la cascade des p38, et l'identification d'anticorps et autres agents inhibant ou activant la transduction des signaux par l'intermédiaire de la p38.

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