Taojiks as modifiers of the beta-catenin pathway and methods...

Details Taojiks as modifiers of the beta-catenin pathway and methods... Taojiks as modifiers of the beta-catenin pathway and methods...

A - Human Necessities

61

K

A61K 38/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2460806

Human TAOJIK genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta- catenin function. Methods for identifying modulators of beta-catenin, comprising screening for agents that modulate the activity of TAOJIK are provided.

Selon l'invention, des gènes TAOJIK sont identifiés en tant que modulateurs de la voie bêta-caténine, et constituent ainsi des cibles thérapeutiques pour des troubles associés à la fonction bêta-caténine défectueuse. L'invention concerne également des procédés d'identification de modulateurs de bêta-caténine, qui consistent à cribler des agents qui modulent l'activité de TAOJIK.

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