Taq dna polymerases having an amino acid substitution at...

Details Taq dna polymerases having an amino acid substitution at... Taq dna polymerases having an amino acid substitution at...

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C12N 1/21 (2006.01) C12N 9/12 (2006.01) C12N 15/70 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2381206

Thermostable DNA polymerases having an E410R substitution which result in a substantial improvement of signal uniformity compared to Taq .DELTA.271/F272M/F667Y DNA polymerase. The instant DNA polymerases possess improved salt tolerance and have been shown to modulate the incorporation of terminators having a net positive or a net negative charge during the sequencing reaction.

Cette invention concerne des ADN polymérases thermostables présentant une substitution E410R qui se traduit par une amélioration sensible de l'uniformité du signal par rapport à l'ADN polymérase Taq .DELTA.271/F272M/F667Y. Les ADN polymérases selon l'invention présentent une tolérance supérieure au sel et modulent l'incorporation de terminateurs à charge négative ou à charge positive nettes pendant la réaction de séquençage.

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