Target

Details Target Target

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 38/46 (2006.01) C07K 7/08 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12Q 1/44 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2351904

The present invention relates to an isolated target sequence. The target sequence is a splice variant of PDE5 called a PDE5a1, a component of which is presented as SEQ ID No 1. The identified target sequence of the present invention may be used to as a target to identify agents (such as modulators) useful in the prevention and/or treatment of a disease associated with scarring and/or fibrosis or to selectively identify smooth muscle cells and myofibroblasts and myoepithelial cells in samples of normal and diseased tissue from individuals.

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