Target genes for allele-specific drugs

Details Target genes for allele-specific drugs Target genes for allele-specific drugs

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A61K 35/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C12N 9/00 (2006.01) C12N 15/00 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2283636

This disclosure concerns genetic targets which have been found to be useful for allele specific anti-tumor therapy. The strategy for such therapy involves the steps of: (1) identification of alternative alleles of genes coding for proteins essential for cell viability or cell growth and the loss of one of these alleles in cancer cells due to loss of heterozygosity (LOH) and (2) the development of inhibitors with high specificity for the single remaining alternative allele of the essential gene retained by the tumor cell after LOH. Particular categories of appropriate target genes are described, along with specific exemplary genes within those categories and methods of using such target genes.

L'invention concerne des cibles génétiques utiles pour des thérapies antitumorales spécifiques d'allèles. La stratégie de tels traitements comporte les étapes consistant à: (1) identifier des allèles distincts de gènes codant pour des protéines essentielles à la vie ou à la croissance des cellules, et à la perte de l'un de ces allèles dans des cellules cancéreuses, due à la perte d'hétérozygotie (LOH); et (2) développer des inhibiteurs présentant une spécificité élevée pour l'allèle distinct restant du gène essentiel retenu par la cellule tumorale après LOH. Des catégories particulières de gènes cibles appropriés sont décrites, ainsi que des gènes servant d'exemples pour ces catégories, et des procédés d'utilisation de tels gènes cibles.

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