C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2087164
A soluble antibody conjugate comprising an antibody linked to a structure which is recognizable by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is characterized by the structure being a superantigen. One important mode is a method for the lysis of target cells, wherein the target cells are contacted with a target cell lysis effective amount of the conjugate. The method of lysis is part of a potent treatment regimen for cancer, autoimmu- nity, parasitic infestations and fungal, viral and bacterial infections. The specification also describes modes such as the synthesis of the conjugate and pharmaceutical compositions and their manufacture.
Akerblom Eva
Dohlsten Mikael
Hedlund Gunnar
Kalland Terje
Lando Peter
Active Biotech Ab
Gowling Lafleur Henderson Llp
Kabi Pharmacia Ab
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