Targetable vector particles

Details Targetable vector particles Targetable vector particles

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 14/15 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/12 (2006.01) C12N 15/48 (2006.01) C12N 15/51 (2006.01) C12N 15/867 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2148934

A vector particle (e.g., a retroviral vector particle) containing a chimeric envelope includes a receptor binding region that binds to a receptor of a target cell. The receptor of the target cell is other than the amphotropic cell receptor. The receptor binding region may be a receptor binding region of a human virus. A portion of the envelope gene may be deleted and the deleted portion is replaced with another receptor binding region or ligand. Such vector particles are targetable to a desired target cell or tissue, and may be administered directly to the desired target cell or tissue as part of a gene therapy procedure, or administered directly into the patient.

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