Targeted adenoviral vector displaying immunoglobulin-binding...

Details Targeted adenoviral vector displaying immunoglobulin-binding... Targeted adenoviral vector displaying immunoglobulin-binding...

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2493254

The present invention provides a targeted recombinant adenovirus vector expressing a fiber protein modified by insertion of an immunoglobulin-binding domain that can crosslink to a fusion protein comprising a targeting ligand and an immunoglobulin Fc domain. Interaction between the immunoglobulin- binding domain and the Fc domain results in a targeted vector::ligand complex, thereby targeting the adenovirus vector to a cell that expresses a cell surface molecule that binds to said targeting ligand.

La présente invention concerne un vecteur adénoviral recombiné, ciblé, exprimant une protéine fibreuse modifiée par insertion d'un domaine de fixation à l'immunoglobuline pouvant former une liaison avec une protéine de fusion comprenant un ligand-cible et un domaine Fc d'immunoglobuline. L'interaction entre le domaine de fixation à l'immunoglobuline et le domaine Fc permet d'obtenir un complexe vecteur ciblé::ligand, et ainsi de diriger le vecteur adénoviral vers une cellule qui exprime une molécule de surface qui se fixe audit ligand-cible.

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