C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 31/52 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C07K 16/08 (2006.01) C12N 7/01 (2006.01) C12N 15/861 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2237059
The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein. The present invention generates an adenovirus with modified fiber gene using a two-plasmid rescue system for derivation of adenoviral fiber recombinants.
La présente invention concerne des moyens destinés à modifier le tropisme de vecteurs adénoviraux recombinés à l'aide de procédés génétiques permettant de modifier la protéine de liaison de cellules des fibres adénovirales. La présente invention génère un adénovirus présentant un gène de fibres modifié utilisant un système de sauvegarde à deux plasmides pour la dérivation d'éléments de recombinaison de fibres adénovirales.
Borden Ladner Gervais Llp
The University Of Alabama At Birmingham Research Foundation
LandOfFree
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