Targeted binding agents directed to upar and uses thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) A61K 47/48 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2649326

Targeted binding agents directed to the antigen uPAR and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen uPAR. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

Agents de liaison ciblés, dirigés contre l'antigène l'uPArR, et utilisations. En particulier, anticorps monoclonaux entièrement humains dirigés contre cet antigène. Séquence nucléotidiques codant, et séquences aminoacides comprenant, des molécules d'immunoglobuline chaîne lourde et légère, en particulier séquences correspondant à des séquences chaîne lourde et légère contiguës s'étendant sur les régions cadres et/ou des régions déterminantes complémentaires, spécifiquement de FR1 à FR4 ou de CDR1 à CDR3. Hybridomes ou autres lignées cellulaires exprimant ces molécules d'immunoglobuline et anticorps monoclonaux.

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