A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/44 (2006.01) C07K 14/74 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01)
Patent
CA 2502735
The invention is directed to a compound comprising one or more CD1d complexes in association with an antibody specific for a cell surface marker. The CD1d complexes comprise a CD1d, a .szlig.2-microglobulin molecule, and may further comprise an antigen bound to the CD1d binding groove. The invention is further directed to methods of inhibiting or stimulating an immune response with the CD1d-antibody compounds, in particular anti-tumor and autoimmunity responses.
L'invention concerne un composé renfermant un ou plusieurs complexes CD1d associés à un anticorps spécifique d'un marqueur de surface cellulaire. Les complexes CD1d comprennent un CD1d, une molécule de .szlig.2-microglobuline, et, éventuellement, un antigène lié au sillon de liaison de CD1d. Cette invention concerne également des méthodes propres à inhiber ou à stimuler une réponse immunitaire au moyen de composés anticorps CD1d, en particulier des réponses anti-tumorales et d'auto-immunité.
Cesson Valerie
Donda Alena
Mach Jean-Pierre
Robert Bruno
Zauderer Maurice
Mbm Intellectual Property Law Llp
Vaccinex Inc.
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