Targeted chimeric molecules for cancer therapy

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/32 (2006.01)

Patent

CA 2593648

The present invention concerns chimeric cancer therapeutic molecules comprising a targeting moiety and an anti-cell proliferation moiety. The anti- cell proliferation moiety may comprise a cytotoxic agent or an apoptosis- inducing factor, in specific embodiments. In particular embodiments, the anti- cell proliferation mechanism of the chimeric molecules comprises apoptotic pathways. In additional embodiments, the chimeric molecules of the present invention provide sensitivity to chemotherapy in a cell that is resistant to the chemotherapy.

La présente invention a trait à des molécules chimériques pour la thérapie du cancer comportant un groupe fonctionnel de ciblage et un groupe fonctionnel contre la prolifération cellulaire. Dans des modes de réalisation spécifiques, le groupe fonctionnel contre la prolifération cellulaire peut comporter un agent cytotoxique ou un facteur induisant l'apoptose. Dans des modes de réalisation particuliers, le mécanisme contre la prolifération cellulaire des molécules chimériques comportent des voies apoptotiques. Dans des modes de réalisation supplémentaires, les molécules chimériques de la présente invention assurent la sensibilité à la chimiothérapie dans une cellule qui est résistante à la chimiothérapie.

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