Targeted coagulation factors and method of using the same

Details Targeted coagulation factors and method of using the same Targeted coagulation factors and method of using the same

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/00 (2006.01) A61K 38/37 (2006.01) A61K 47/48 (2006.01) C07K 14/755 (2006.01) C07K 16/28 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2724630

Targeted coagulation factors comprising a coagulation factor linked with at least one domain that specifically binds to a membrane protein on a blood cell is provided. The disclosed targeted coagulation factors increase the efficiency of coagulation factors and prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.

L'invention concerne des facteurs de coagulation ciblés qui comportent un facteur de coagulation lié à au moins un domaine qui se lie de manière spécifique à une protéine membranaire sur une cellule sanguine. Les facteurs de coagulation ciblés décrits augmentent l'efficacité des facteurs de coagulation et prolongent leur durée d'action et, ainsi, sont une amélioration pour le traitement de maladies hématologiques telles que l'hémophilie A.

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