Targeted delivery of bone growth factors

Details Targeted delivery of bone growth factors Targeted delivery of bone growth factors

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2102808

2102808 9220371 PCTABS00017 Methods and compositions for using conjugates of bone growth factors and targeting molecules in bone repair and augmentation are provided. The bone growth factor and targeting molecule are chemically conjugated to a crosslinker. The crosslinker is preferably a synthetic hydrophilic polymer. The bone growth factor is preferably TGF-.beta., activin, or bone morphogenic protein (BMP). Targeting molecules preferably have an affinity for bone, such as tetracycline, calcein, bisphosphonate, polyaspartic acid, polyglutamic acid, aminophosphosugars, or estrogen.

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