Targeted delivery of genes encoding immunogenic proteins

Details Targeted delivery of genes encoding immunogenic proteins Targeted delivery of genes encoding immunogenic proteins

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 31/70 (2006.01) A61K 39/29 (2006.01) A61K 39/42 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 16/00 (2006.01) C07K 16/08 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2103064

2103064 9220316 PCTABS00017 Molecular complexes can be used to target a gene encoding an immunogenic protein or polypeptide to a specific cell in vivo. The gene is incorporated into the target cell, expressed and the gene-encoded product is secreted and an immune response against the immunogenic protein or polypeptide is elicited. The molecular complex comprises an expressible gene encoding a desired immunogenic protein or polypeptide complexed with a carrier of a cell-specific binding agent and a gene-binding agent. The cell-specific binding agent is specific for a cellular surface structure which mediates internalization of ligands by endocytosis. An example is the asialoglycoprotein receptor of hepatocytes. The gene-binding agent is a compound such as a polycation which stably complexes the gene under extracellular conditions and releases the gene under intracellular conditions so that it can function within a cell. The molecular complex is stable and soluble in physiological fluids and can be used to elicit an immune response against a variety of immunogens in an organism for the purpose of vaccination or for the production of antibodies.

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