Targeted delivery of growth factors for bone regeneration

Details Targeted delivery of growth factors for bone regeneration Targeted delivery of growth factors for bone regeneration

C - Chemistry, Metallurgy

07

K

C07K 2/00 (2006.01) A61K 38/18 (2006.01) A61K 38/30 (2006.01) A61K 47/48 (2006.01) C07F 9/38 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2139323

Specific target delivery composition systems where growth factors are linked, optionally using an acid cleavable linker, to a polyaminomethylenephosphonic acid ligand and are especially suitable for site delivery to bone. When the acid cleavable linker is present, the composition is activated for the growth factors at the bone site while it remains inactive while circulating in the body. Process to make the compound and composition are also taught.

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