Targeted delivery of lidocaine and other local anesthetics...

Details Targeted delivery of lidocaine and other local anesthetics... Targeted delivery of lidocaine and other local anesthetics...

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 9/14 (2006.01) A61K 31/24 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2581209

An anti-tussive nebulized solution for targeted delivery of lidocaine into conducting and central airways. A method for treatment of cough and tussive attacks or episodes using said lidocaine solution. A nebulized lidocaine solution administered in daily dose from about 10 mg to 80 mg of lidocaine dissolved in a saline and nebulized into an aerosol having a mass median aerodynamic diameter 3 ~m to 10 ~m and a geometric standard deviation less than 1.7 using an electronic nebulizer.

Cette invention concerne une solution en vaporisation anti-toux destinée à une distribution ciblée de lidocaïne dans les voies respiratoires de conduction et centrales. Elle concerne également un procédé de traitement de la toux et des attaques ou épisodes laryngés par l~utilisation de cette solution de lidocaïne. Cette solution de lidocaïne en vaporisation est administrée en dose quotidienne d'environ 10 mg à 80 mg de lidocaïne dissoute dans une solution salée et vaporisée avec un aérosol d~un diamètre aérodynamique médian massique de 3 µm à 10 µm et d~un écart-type géométrique inférieur à 1,7, au moyen d~un nébuliseur électronique.

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