C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01) C12N 15/867 (2006.01)
Patent
CA 2659529
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.
L'invention concerne des procédés et des compositions pour l'administration d'un polynucléotide codant pour un gène d'intérêt, typiquement un antigène, à une cellule dendritique (DC). L'enveloppe virale comprend une molécule de ciblage spécifique de DC-SIGN. Les procédés et les compositions apparentées peuvent être utilisés pour traiter des patients souffrant d'une large gamme d'états, y compris les infection dont le VIH/SIDA, et divers types de cancers.
Baltimore David
Wang Pin
Yang Lili
Borden Ladner Gervais Llp
California Institute Of Technology
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