C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 47/48 (2006.01) C07K 14/01 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2329908
This invention provides methods specifically delivering and expressing heterologous nucleic acids in target cells. The methods generally involve providing a phage externally displaying a heterologues targeting protein (e.g., a scFv) and containing a heterologous nucleic acid; and contacting the target cell with the said phage whereby the phage is internalized into the cell and wherein the heterologous nucleic acid is transcribed, and optionally translated, within the cell.
L'invention porte sur des procédés visant à administrer et exprimer spécifiquement des acides nucléiques hétérologues dans des cellules cibles. Ces procédés consistent généralement à produire un phage présentant extérieurement une protéine de ciblage hétérologue (telle que scFv) et contenant un acide nucléique hétérologue ; et mettre en contact la cellule cible avec le phage, ce dernier étant internalisé dans la cellule, et l'acide nucléique hétérologue est transcrit, puis éventuellement traduit, dans la cellule.
Becerril Baltazar
Marks James D.
Poul Marie Alix
Smart & Biggar
The Regents Of The University Of California
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