Targeted gene delivery to non-phagocytic mammalian cells via...

Details Targeted gene delivery to non-phagocytic mammalian cells via... Targeted gene delivery to non-phagocytic mammalian cells via...

A - Human Necessities

61

K

A61K 47/00 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2549840

A method of targeting bacterially-derived, intact minicells to specific, non- phagocytic mammalian cells employs bispecific ligands to deliver nucleic acids efficiently to the mammalian cells. Bispecific ligands, comprising (i) a first arm that carries specificity for a bacterially-derived minicell surface structure and (ii) a second arm that carries specificity for a non-phagocytic mammalian cell surface receptor are useful for targeting minicells to specific, non-phagocytic mammalian cells and causing endocytosis of minicells by non-phagocytic cells.

L'invention concerne une méthode d'administration ciblée de minicellules intactes dérivées de bactéries à des cellules mammifères non phagocytaires spécifiques. Cette méthode fait appel à des ligands bispécifiques pour administrer efficacement des acides nucléiques à des cellules mammifères. Ces ligands bispécifiques, lesquels comportent (i) un premier bras portant une spécificité pour une structure de surface des minicellules dérivées de bactéries et (ii) un deuxième bras portant une spécificité pour un récepteur de surface des cellules mammifères non phagocytaires, sont utiles pour permettre l'administration ciblée de minicellules à des cellules mammifères non phagocytaires spécifiques et pour provoquer l'endocytose des minicellules par les cellules non phagocytaires.

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