Targeted induction of aggregation of proteins with cross...

Details Targeted induction of aggregation of proteins with cross... Targeted induction of aggregation of proteins with cross...

C - Chemistry, Metallurgy

07

K

C07K 1/32 (2006.01) A61K 38/00 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2689120

The present invention belongs to the field of protein aggregation. The invention discloses a method for interfering with the function of a target protein and uses a non-naturally, user-designed molecule, designated as aggregator, that has a specificity for a target protein and which induces aggregation upon contact with said target protein. The present invention also discloses such aggregator molecules and their use in therapeutic and diagnostic applications.

La présente invention concerne le domaine de l'agrégation des protéines. Cette invention porte sur un procédé permettant d'interférer avec la fonction d'une protéine cible et fait appel à une molécule non naturelle spécifiquement conçue par l'utilisateur, qui est appelée agrégateur et qui présente une spécificité pour une protéine cible et qui induit l'agrégation lors du contact avec ladite protéine cible. Cette invention concerne également de telles molécules agrégateur et leur utilisation dans des applications de thérapie et de diagnostic.

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