Targeted innate immunity

Details Targeted innate immunity Targeted innate immunity

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07H 21/00 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2586913

Provided is a cancer therapeutic agent comprising a cancer targeting molecule linked to a CpG oligodeoxynucleotide. Also provided are methods of reducing the size of a tumor or inhibiting the growth of cancer cells in an individual or inhibiting the development of metastatic cancer, comprising administering an effective amount of the cancer therapeutic agent. The methods may also include reducing immunoregulatory T cell activity in the individual.

L'invention concerne un agent anticancéreux comprenant une molécule ciblant le cancer lié à un oligodéoxynucléotide CpG. L'invention concerne également des procédés de réduction de la taille d'une tumeur ou l'inhibition de la croissance de cellules cancéreuses chez un individu ou l'inhibition du développement d'un cancer métastatique, par administration d'une quantité efficace de l'agent anticancéreux. Ces procédés peuvent également consister à réduire l'activité des lymphocytes T immunorégulateurs chez un individu.

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