C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/21 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 14/555 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2699944
This invention provides novel chimeric moieties that show significant efficacy against cancers. In certain embodiments the chimeric moieties comprise a targeting moiety attached to an interferon. In certain embodiments, the chimeric moieties comprise fusion proteins where an antibody that specifically binds to a cancer marker is fused to interferon alpha (IFN-.alpha.).
La présente invention concerne de nouvelles fractions chimériques qui présentent une efficacité significative contre des cancers. Dans certains modes de réalisation, les fractions chimériques comprennent une fraction de ciblage attachée à un interféron. Dans certains modes de réalisation, les fractions chimériques comprennent des protéines de fusion où un anticorps qui se lie spécifiquement à un marqueur de cancer est fusionné à l'interféron alpha (IFN-a).
Huang Tzu-Hsuan
Morrison Sherie L.
Xuan Caiyun
Smart & Biggar
The Regents Of The University Of California
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