Targeted iron chelator delivery system

Details Targeted iron chelator delivery system Targeted iron chelator delivery system

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 9/133 (2006.01) A61K 31/16 (2006.01) A61K 39/44 (2006.01)

Patent

CA 2589359

A targeted iron chelator delivery system that comprises an iron chelator, a targeting agent and a lipid carrier, e.g., a liposome, is provided. The iron chelator delivery system may be used to remove excess iron from specific organs such as, for example, heart and liver tissue. Methods for preparing and administering the targeted iron chelator delivery system are also provided. The iron chelator delivery system may be administered during a blood transfusion to prevent iron overload.

L'invention concerne un système de distribution de chélateur du fer ciblé, qui comprend un chélateur du fer, un agent de ciblage et un support lipidique, par exemple un liposome. Le système de distribution de chélateur du fer peut être utilisé pour éliminer un excès de fer d'organes, tels que, par exemple, le coeur ou le tissu hépatique. L'invention concerne également des méthodes de préparation et d'administration du système de distribution de chélateur du fer. Le système de distribution de chélateur du fer peut être administré au cours d'une transfusion sanguine pour empêcher une surcharge de fer.

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