Targeted ligands

Details Targeted ligands Targeted ligands

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C40B 40/08 (2006.01) C40B 40/10 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2441653

The invention contemplates a composition containing a multispecific ligand containing at least a first ligand binding moiety and a second ligand binding moiety. The first ligand binding moiety specifically binds with a pre-selected first affinity to at least a first ligand. The first ligand has a first biodistribution. The second ligand binding moiety specifically binds with a pre-selected affinity to at least a second ligand. The second ligand has a second biodistribution. The affinities of first and second ligand binding moieties are selected to bias the biodistribution of the multispecific ligand in favour of a selected location of one or both of the ligands.

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