Targeted liposomes and methods for liposome-protein coupling

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/127 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) B01J 13/00 (2006.01)

Patent

CA 2296884

This invention relates to a method for synthesizing a substantially pure reactive lipid including, for example, N-[4-(p-maleimidophenyl)-butyryl]phosphatidylethanolamine (MPB-PE) and related compositions. The compositions of the present invention are useful as coupling agents and may be incorporated into liposomes and subsequently coupled to proteins, cofactors and a number of other molecules. A preferred coupling method is also disclosed as are protein conjugates.

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