Targeted nucleic acid constructs and uses related thereto

Details Targeted nucleic acid constructs and uses related thereto Targeted nucleic acid constructs and uses related thereto

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2458780

The invention provides targeted constructs comprising a targeting moiety, a nucleic acid, and payload. The payload can be a detectable label or a therapeutic agent. The nucleic acid can be an antisense molecule that is complementary to RNA present in a target cell. The targeted constructs can be used to introduce the payload into a target cell in vivo or in vitro. Accordingly, the invention can be used for diagnostic purposes and for therapeutic purposes.

Cette invention concerne des produits de recombinaison ciblés comprenant une fraction de ciblage, un acide nucléique et une charge utile. La charge utile peut être un marqueur détectable ou un agent thérapeutique. L'acide nucléique peut être une molécule antisens qui est complémentaire de l'ARN présent dans une cellule cible. Les produits de recombinaison ciblés peuvent être utilisés pour introduire la charge utile dans une cellule cible, in vivo or in vitro. Cette invention peut donc s'utiliser à des fins diagnostiques et thérapeutiques.

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