Targeted plasminogen activator fusion proteins as...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 19/00 (2006.01) A61K 38/49 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 16/18 (2006.01) C12N 9/64 (2006.01) C12N 9/72 (2006.01) A61K 38/16 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2601271

This invention relates to novel fusion proteins, comprising a targeting protein and a plasminogen activator, preferably an antibody that binds to P- selectin, operably linked to the plasminogen activator DSPAalphal, or analogs, frag~ments, derivatives, or variants thereof, which are useful as thrombolytic agents. Pharmaceutical compositions containing these fusion proteins, methods of using these fusion proteins as thrombolytic agents, and processes for synthe~sizing these fusion proteins are also described herein.

L~invention concerne de nouvelles protéines de fusion, qui comportent une protéine de ciblage et un activateur du plasminogène, de préférence un anticorps qui se lie à la sélectine P et qui est lié de manière fonctionnelle à l~activateur du plasminogène DSPAalphal, ou des analogues, fragments, dérivés ou variantes, qui sont utiles en tant qu~agents thrombolytiques. L'invention concerne également des compositions pharmaceutiques qui contiennent ces protéines de fusion, les méthodes d~utilisation de ces protéines de fusion en tant qu~agents thrombolytiques et les procédés de synthèse de ces protéines de fusion.

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