A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 31/59 (2006.01)
Patent
CA 2279590
The present invention is directed to a conjugate which includes at least one vitamin D moiety thereof and at least one targeting molecule moiety to pharmaceutical compositions of the conjugate, and to methods for using the conjugate for target-specific delivery of vitamin D or analogs thereof to tissues in need thereof. When a particularly preferred form is administered to a patient, the targeting molecule component of the conjugate of this invention seeks out and binds to a tissue of interest, such as bone or tumor tissue, where the vitamin D has a therapeutic effect.
La présente invention concerne un conjugué comprenant au moins une fraction de vitamine D et au moins une fraction de molécule de ciblage de compositions pharmaceutiques du conjugué; l'invention concerne également des méthodes d'utilisation du conjugué pour une administration ciblée de vitamine D ou d'analogues de vitamine D à des tissus les nécessitant. Lorsqu'une forme particulièrement préférée est administrée à un patient, le composant de molécule de ciblage du conjugué de la présente invention repère un tissu intéressant, tel qu'un tissu osseux ou tumoral, et se lie à ce tissu où la vitamine D exerce un effet thérapeutique.
Bishop Charles W.
Mazess Richard B.
Bone Care International Inc.
Shapiro Cohen
LandOfFree
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