Targeted therapeutic proteins

Details Targeted therapeutic proteins Targeted therapeutic proteins

A - Human Necessities

61

K

A61K 38/47 (2006.01) A61K 38/00 (2006.01) A61K 38/06 (2006.01) A61K 38/08 (2006.01) A61K 38/30 (2006.01) A61K 47/48 (2006.01) C07K 14/65 (2006.01)

Patent

CA 2487815

Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.

L'invention concerne des produits thérapeutiques qui se localisent dans un compartiment infracellulaire spécifique, tel que le lysosome. Les produits thérapeutiques ciblés comprennent un agent thérapeutique et un fragment de ciblage qui se lie à un récepteur sur une surface extérieure de la cellule, ce qui assure une localisation infracellulaire appropriée des produits thérapeutiques après internalisation du récepteur. L'invention concerne en outre des acides nucléiques, des cellules et des méthodes se rapportant à la mise en oeuvre des produits de l'invention.

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