Targeting and prolonging association of drugs to the luminal...

Details Targeting and prolonging association of drugs to the luminal... Targeting and prolonging association of drugs to the luminal...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01)

Patent

CA 2339487

Methods for targeting and prolonging association of a selected drug to the luminal surface of pulmonary vascular endothelium of an animal are provided wherein a selected drug is administered to an animal in combination with a non- internalizable antibody which binds to an antigen on the luminal surface of the pulmonary vasculature. This method is particularly useful in dissolution of fibrin clots or prevention of the intravascular coagulation in the pulmonary vasculature.

L'invention porte sur un procédé ciblant un médicament donné sur la surface luminaire de l'endothélium vasculaire pulmonaire d'un animal et en prolongeant l'association avec ledit endothélium. Le médicament s'administre en combinaison avec un anticorps non internalisable qui se fixe à un antigène de la surface luminaire de la vasculature pulmonaire. Ce procédé s'avère particulièrement utile pour dissoudre les caillots de fibrine ou prévenir les coagulations intravasculaires dans la vasculature pulmonaire.

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