C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/435 (2006.01)
Patent
CA 2656063
The invention provides a CR2-FH molecule comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising a CR2-FH molecule. Also provided are methods of using the compositions for treatment diseases in which the alternative complement pathway is implicated, such as age- related macular degeneration, rheumatoid arthritis, and ischemia reperfusion.
La présente invention concerne une molécule de CR2-FH contenant une partie CR2 renfermant une protéine CR2 ou un fragment de celle-ci, et une partie FH renfermant une protéine de facteur H ou un fragment de celle-ci, ainsi que des compositions pharmaceutiques contenant une molécule CR2-FH. L'invention concerne également des procédés d'utilisation des compositions pour le traitement de maladies impliquant la voie alternative du complément, telles qu'une dégénérescence maculaire liée au vieillissement, une polyarthrite rhumatoïde, et une reperfusion ischémique.
Gilkeson Gary
Holers V. Michael
Rohrer Baerbel
Tomlinson Stephen
Borden Ladner Gervais Llp
Musc Foundation For Research Development
The Regents Of The University Of Colorado
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