Targeting compositions and preparation thereof

Details Targeting compositions and preparation thereof Targeting compositions and preparation thereof

C - Chemistry, Metallurgy

07

K

C07K 7/64 (2006.01) A61K 38/12 (2006.01) A61K 38/55 (2006.01) A61P 35/00 (2006.01) C07K 14/81 (2006.01)

Patent

CA 2542684

The present invention relates to targeted cancer therapy and tumour imaging, and concerns specifically new derivatives of small matrix metalloproteinase inhibitor peptides. These new derivates are the hydrophilic peptides GRENYHGCTTHWGFTLC and derivates thereof. These peptides have an increased solubility and may be used in the preparation of targeting compositions together with suitable linker molecules such as PEG. Such targeting compositions are useful in therapeutics and imaging liposome compositions for cancer treatment and diagnostics.

La présente invention se rapporte à la thérapie de cancer ciblée et à l'imagerie de tumeurs et plus particulièrement aux nouveaux dérivés de petits peptides inhibiteurs de la métalloprotéinase matricielle. Ces nouveaux dérivés sont les peptides hydrophiles GRENYHGCTTHWGFTLC et leurs dérivés. Ces peptides présentent une solubilité améliorée et peuvent être utilisés dans la préparation de compositions de ciblage avec des molécules de liants adaptées, notamment PEG. De telles compositions de ciblage sont utilisées dans le traitement et l'imagerie de compositions liposomiques pour le traitement et le diagnostic du cancer.

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