Targeting endothelium for tissue-specific delivery of agents

Details Targeting endothelium for tissue-specific delivery of agents Targeting endothelium for tissue-specific delivery of agents

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 47/48 (2006.01) A61K 51/00 (2006.01) A61K 51/08 (2006.01)

Patent

CA 2537899

Mechanisms and routes by which molecules can be delivered into cells, particularly endothelial cells, through the action of caveolae, G domains and other plasma membrane domains and components, are described, as are delivery systems comprising antibodies to caveolar proteins or receptors and also agents conjugated to the antibody or ligand, which can be used to deliver agents to, into, and/or across the endothelium, for example, for imaging purposes.

L'invention porte sur des mécanismes et des voies d'administration par lesquels des molécules peuvent être envoyées dans des cellules, notamment les cellules endothéliales, sous l'action de caveolae, des domaines G et d'autres domaines de la membrane cellulaire et de composants, ainsi que sur des systèmes d'administration comprenant des anticorps destinés à des protéines cavéolaires ou des récepteurs, et également des agents conjugués à l'anticorps ou au ligand, ces systèmes pouvant être utilisés pour administrer des agents vers, dans et/ou par l'endothélium, par exemple, à des fins d'imagerie.

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