A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/64 (2006.01) A61K 31/196 (2006.01) A61K 31/455 (2006.01) A61K 45/00 (2006.01) A61P 9/10 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2674949
The present invention concerns protection of an organ or tissue following an ischemic episode In particular aspects, the invention concerns organ preservation for transplantation, angina pectoris, kidney reperfusion injury, and so forth In specific embodiments, the organ is subjected to an inhibitor of an NCCa-ATP channel that is regulated by SURl Exemplary inhibitors include sulfonylurea compounds, such as glibenclamide, for example
L'invention concerne la protection d'organes ou de tissus à l'extérieur du système nerveux central après un épisode ischémique. Dans des aspects particuliers, l'invention concerne la conservation d'organes pour une transplantation, une angine de poitrine, une lésion de reperfusion du rein, entre autres. Dans des modes de réalisation spécifiques, l'organe est soumis à un inhibiteur de canal NCca-ATP régulé par SURI. Parmi les inhibiteurs exemplaires, on peut citer des composés de sulfonylurée, tel que le glibenclamide, par exemple.
Borden Ladner Gervais Llp
University Of Maryland Baltimore
LandOfFree
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